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Mar 26, 2025

Coupling reactions using iron–sodium pairs | Nature Synthesis

Catalysis Nature Synthesis (2025)Cite this article Metrics details Organosodium reagents have long been considered too reactive for application in organic synthesis. Now, sodium-based nucleophiles can

Catalysis

Nature Synthesis (2025)Cite this article

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Organosodium reagents have long been considered too reactive for application in organic synthesis. Now, sodium-based nucleophiles can be used with iron catalysis to enable C(sp2) homo-coupling and C(sp2)–C(sp3) cross-coupling reactions.

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Inorganic Chemistry Laboratory, University of Oxford, Oxford, UK

Jos Briggs-Pritchard & Michael L. Neidig

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Correspondence to Michael L. Neidig.

The authors declare no competing interests.

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Briggs-Pritchard, J., Neidig, M.L. Coupling reactions using iron–sodium pairs. Nat. Synth (2025). https://doi.org/10.1038/s44160-025-00779-7

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Published: 26 March 2025

DOI: https://doi.org/10.1038/s44160-025-00779-7

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